The Hypoglycaemic Sulphonylureas

Sulphonylureas and hypoglycaemia.

The hypoglycaemic action of metformin.

Twenty-four-hour excretion of D-xylose after oral administration in nine diabetic patients, and of 3-0methyl-D-glucose in six patients, showed no significant change after treatment with metformin. There was, however, a significant reduction in mean fasting blood glucose levels in thirteen patients from 160 to 115 mg/ 100 ml (P <0001), and the intravenous glucose tolerance improved in twelve of ...

Hypoglycaemic coma with chlorpropamide.

MILD hypoglycaemic reactions are well recognized as a complication of chlorpropamide therapy, and have been estimated as occurring in 7% of all cases (Stowers & Bewsher, 1962). Severe hypoglycaemic coma due to this drug seems, however, to have been infrequently recognized, and we have been able to find only four isolated reports of this condition in the literature (Coates & Robbins, 1959; Bloch...

Exercise induced hypoglycaemic hyperinsulinism.

BACKGROUND Hyperinsulinism in childhood is often caused by genetic defects involving the regulation of insulin secretion leading to recurrent episodes of hypoglycaemia. We report two patients with exercise induced hypoglycaemia. METHODS Standardised short exercise tests with frequent blood glucose and plasma insulin measurements were performed in the patients and young healthy controls. RES...

Oral hypoglycaemic drugs.

DIABETES mellitus is a chronic disease which derives its name from the fact that the urine is plentiful and sweet-tasting. About 1-2 per cent of the adult population of the United Kingdom suffer from the condition which develops either when the production of insulin (the internal secretion of the pancreas) is inadequate or, alternatively, when the action of insulin on the tissues is antagonized...